AG6033

AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect[1].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

CRBN

AG6033 (0.064-40 μM, 4 h) has potent inhibition ability against A549[1]. AG6033 (1-10 μM, 24 h) significantly promotes apoptosis of A549 cells in a dose-dependent manner[1]. Cell Proliferation Assay Cell Line: A549 cells[1] Concentration: 0.064 μM, 0.32 μM, 1.6 μM, 8 μM, and 40 μM Incubation Time: 4 h Result: Exhibited potent inhibitory ability against A549, with an IC50 of 0.853 μM. Apoptosis Analysis Cell Line: A549 cells[1] Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 24 h Result: Significantly promoted apoptosis of A549 cells in a dose-dependent manner, and the proportion of late apoptotic cells were 5.39%, 22.0%, and 29.1%, respectively.

[1]. Xiong F, Kong L, Chen L, et al. Discovery of potential novel CRBN modulators by virtual screening and bioassay. Eur J Med Chem. 2022 Apr 5;236:114355.