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PTP Inhibitor IV

Names

[ CAS No. ]:
329317-98-8

[ Name ]:
PTP Inhibitor IV

[Synonym ]:
Methanesulfonamide, N,N'-[1,4-phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1-trifluoro-
N,N'-[1,4-Phenylenebis(2,2-propanediyl-4,1-phenylene)]bis(1,1,1-trifluoromethanesulfonamide)
PTP Inhibitor IV

Biological Activity

[Description]:

PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM[1]. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

IC50: 1.8 μM (SHP-2), 2.5 μM (PTP1B), 8.4 μM (PTP-ε), 13 μM (PTP Meg-2), 20 μM (PTP-σ), 6.4 μM (PTP-β), and 6.7 μM (PTP-μ)[2]; 5.21 μM (DUSP14)[1]


[In Vitro]

PTP Inhibitor IV 通过结合在催化位点下调 DUSP14 的催化活性[1]。 PTP Inhibitor IV（0-100 μM；3 小时）有效且特异性地抑制 DUSP14 介导的 JNK 去磷酸化[1]。 Western Blot Analysis[1] Cell Line: HEK 293 cells Concentration: 0, 10 μM, 50 μM, or 100 μM Incubation Time: 3 hours Result: Effectively penetrated the cells and inhibited DUSP14 activity.

[References]

[1]. Jae Eun Park, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9.  

[2]. Ping Huang, et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorg Med Chem. 2003 Apr 17;11(8):1835-49.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
578.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H26F6N2O4S2

[ Molecular Weight ]:
608.616

[ Flash Point ]:
303.4±32.9 °C

[ Exact Mass ]:
608.123840

[ LogP ]:
9.41

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.560

[ Storage condition ]:
2-8°C

Related Compounds