5-methylaminomethyl-2-thiouridine

Names

[ Name ]:
5-methylaminomethyl-2-thiouridine

[Synonym ]:
5-methylaminomethyl-2-thiouridine
Uridine,5-[(methylamino)methyl]-2-thio
2-Thio-5-(N-methylaminomethyl)uridine
5-N-Methylaminomethyl-2-thiouridine
2-Thio-5-methylaminomethyluridine

Biological Activity

[Description]:

Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

An E. coli strain deficient in mnm5s2U is more vulnerable to oxidative RNA damage compared to its wildtype strain suggesting an auxiliary function for the mnm5s2U modification[1].

[References]

[1]. Mariana Estevez, et al. Oxidative Damage to RNA is Altered by the Presence of Interacting Proteins or Modified Nucleosides. Front Mol Biosci. 2021 Jul 1;8:697149.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₇N₃O₅S

[ Molecular Weight ]:
303.33500

[ Exact Mass ]:
303.08900

[ PSA ]:
152.09000

Related Compounds

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