JNJ-9350
Names
[ CAS No. ]:
326923-09-5
[ Name ]:
JNJ-9350
Biological Activity
[Description]:
JNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer[1].
[Related Catalog]:
[Target]
IC50: 10 nM (SMOX), 790 nM (PAO), ＞60 μM (LSD1)[1]
[In Vitro]
JNJ-9350 (0-100 μM) shows inhibitory effect to SMOX, PAO and LSD1 with IC50 values of 10 nM, 790 nM and ＞60 μM, respectively[1]. JNJ-9350 (1.1-70 µM) binds with SMOX with a Ki value of 9.9 nM [1].
[In Vivo]
1.19Pharmacokinetic Properties of JNJ-9350 in Mice [1]. Mice PO 10 mg/kg Clearance (mL/min/kg) (Total/Unbound) 73/5217 Volume of distribution (L/kg) 1.7 Half-life (min) 16 PPB (Mouse) 98.6% Oral F% 34%
[References]
[1]. SMOx PROBE PROPOSAL
Chemical & Physical Properties
[ Molecular Formula ]:
C25H22N6O
[ Molecular Weight ]:
422.48