326923-09-5
326923-09-5 structure
- Name: JNJ-9350
- Chemical Name: JNJ-9350
- CAS Number: 326923-09-5
- Molecular Formula: C25H22N6O
- Molecular Weight: 422.48
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2022-11-21 15:18:25
- Modify Date: 2024-09-18 16:09:09
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JNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer[1].
| Name | JNJ-9350 |
|---|
| Description | JNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 10 nM (SMOX), 790 nM (PAO), ＞60 μM (LSD1)[1] |
| In Vitro | JNJ-9350 (0-100 μM) shows inhibitory effect to SMOX, PAO and LSD1 with IC50 values of 10 nM, 790 nM and ＞60 μM, respectively[1]. JNJ-9350 (1.1-70 µM) binds with SMOX with a Ki value of 9.9 nM [1]. |
| In Vivo | 1.19Pharmacokinetic Properties of JNJ-9350 in Mice [1]. Mice PO 10 mg/kg Clearance (mL/min/kg) (Total/Unbound) 73/5217 Volume of distribution (L/kg) 1.7 Half-life (min) 16 PPB (Mouse) 98.6% Oral F% 34% |
| References |
[1]. SMOx PROBE PROPOSAL |
| Molecular Formula | C25H22N6O |
|---|---|
| Molecular Weight | 422.48 |