Febrifugine dihydrochloride

Names

[ Name ]:
Febrifugine dihydrochloride

[Synonym ]:
Febrifugine dihydrochloride [MI]
2-Propanol,1-((6-hydrazinyl-3-pyridazinyl)methylamino)-,hydrochloride (1:2)
UNII-K922TFG9SM
Pildralazine dihydrochloride [MI]
1-((6-Hydrazinyl-3-pyridazinyl)methylamino)-2-propanol
3-(3-((2R,3S)-3-Hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone dihydrochloride
Febrifugine dihydrochloride

Biological Activity

[Description]:

Febrifugine dihydrochloride is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77.

[2]. Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77.

Chemical & Physical Properties

[ Melting Point ]:
220-222 °C (decomp)

[ Molecular Formula ]:
C₁₆H₂₁Cl₂N₃O₃

[ Molecular Weight ]:
374.26200

[ Exact Mass ]:
373.09600

[ PSA ]:
84.22000

[ LogP ]:
2.40140

[ Appearance of Characters ]:
powder，off-white to gray to brown

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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