FSL-1

Names

[ Name ]:
FSL-1

[Synonym ]:
S-[(2R)-2,3-Bis(palmitoyloxy)propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine
L-Phenylalanine, S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-

Biological Activity

[Description]:

FSL-1 is a TLR2/6 agonist (also a putative TLR10 ligand). FSL-1 activates NF-κB. FSL-1 induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. FSL-1 synergizes with IFNγ to induce CXCL10 release from melanoma cells.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Infection

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1659.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈₄H₁₄₀N₁₄O₁₈S

[ Molecular Weight ]:
1666.158

[ Flash Point ]:
957.6±34.3 °C

[ Exact Mass ]:
1665.019043

[ LogP ]:
15.83

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.553

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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