Methylenedioxybenzylpiperazine

Names

[ Name ]:
Methylenedioxybenzylpiperazine

[Synonym ]:
1-(1,3-Benzodioxol-5-yl-methyl)piperazine
1-piperonylpiperazine
1-(3,4-Methylenedioxybenzyl)piperazine
EINECS 250-968-5
1-[(3,4-methylenedioxyphenyl)methyl]piperazine
Piperazine,1-(3,4-methylenedioxybenzyl)
1-Benzo[1,3]dioxol-5-ylmethyl-piperazine
4-(3,4-methylenedioxybenzyl)piperazine
5-(piperazinylmethyl)-2H-benzo[d]1,3-dioxolene
1-(1,3-Benzodioxol-5-ylmethyl)piperazine
piperonylpiperazine
1-[(1,3-Benzodioxol-5-yl)methyl]piperazine
MFCD00005834
Methylenedioxybenzylpiperazine
Piperazine, 1-(1,3-benzodioxol-5-ylmethyl)-
1-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
330.5±0.0 °C at 760 mmHg

[ Melting Point ]:
36-40 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₆N₂O₂

[ Molecular Weight ]:
220.268

[ Flash Point ]:
158.4±26.5 °C

[ Exact Mass ]:
220.121185

[ PSA ]:
33.73000

[ LogP ]:
1.22

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.577

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM1550000

CHEMICAL NAME :: Piperazine, 1-(3,4-methylenedioxybenzyl)-

CAS REGISTRY NUMBER :: 32231-06-4

BEILSTEIN REFERENCE NO. :: 0885038

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H16-N2-O2

MOLECULAR WEIGHT :: 220.30

WISWESSER LINE NOTATION :: T56 BO DO CHJ G1- DT6M DNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,555,1974

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
3259

[ WGK Germany ]:
3

[ RTECS ]:
TM1550000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effects of benzylpiperazine derivatives on the neurotoxicity of 3,4-methylenedioxymethamphetamine in rat brain.

Brain Res. 590(1-2) , 341-4, (1992)

The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was attenuated significantly by coadministration of several benzylpiperazines (p-nitrobenzylpiperazine, p-chlorobenzylpiperaz...

A novel caffeic acid-1-piperonylpiperazine hybridization compound HBU-47 inhibits LPS-mediated inflammation in RAW264.7 macrophage cells.

Int. Immunopharmacol. 19(1) , 60-5, (2014)

In the present study, we synthesized a new hybrid compound by coupling caffeic acid and 1-piperonylpiperazine. The synthetic compound, acetyl-caffeic acid-1-piperonylpiperazine (HBU-47), showed potent...

Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain by 1-piperonylpiperazine.

Eur. J. Pharmacol. 228(2-3) , 171-4, (1992)

The effects of 1-piperonylpiperazine and N,alpha-dimethylpiperonylamine, which are weak inhibitors for [3H]5-hydroxytryptamine (5-HT) uptake, on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurot...