(Trimethylsilyl)methanol
Names
[ CAS No. ]:
3219-63-4
[ Name ]:
(Trimethylsilyl)methanol
[Synonym ]:
(Trimethylsilyl)methanol
1-TRIMETHYLSILYLMETHANOL
Trimethylhydroxymethylsilane
TriMethylsilylMethanol
Methanol, 1-(trimethylsilyl)-
methoxytrimethylsilane
EINECS 221-746-5
trimethylsilanyl-methanol
Hydroxymethyltrimethylsilane
(Hydroxymethyl)trimethylsilane
MFCD00004596
Chemical & Physical Properties
[ Density]:
0.8±0.1 g/cm3
[ Boiling Point ]:
119.8±13.0 °C at 760 mmHg
[ Melting Point ]:
<0ºC
[ Molecular Formula ]:
C4H12OSi
[ Molecular Weight ]:
104.223
[ Flash Point ]:
31.1±0.0 °C
[ Exact Mass ]:
104.065742
[ PSA ]:
20.23000
[ LogP ]:
0.83
[ Vapour Pressure ]:
7.6±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.398
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PC4100000
- CHEMICAL NAME :
- Methanol, (trimethylsilyl)-
- CAS REGISTRY NUMBER :
- 3219-63-4
- BEILSTEIN REFERENCE NO. :
- 1731486
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C4-H12-O-Si
- MOLECULAR WEIGHT :
- 104.25
- WISWESSER LINE NOTATION :
- Q1-SI-1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1080 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933- Volume(issue)/page/year: 229,1011,1976
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R10
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
UN 1987 3/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
PC4100000
[ Packaging Group ]:
III
[ Hazard Class ]:
3
[ HS Code ]:
2931900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2931900090
[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%
Articles
Enzyme Microb. Technol. 16(4) , 328-33, (1994)
Enantioselective esterification of naproxen, 2-(6-methoxy-2-naphthyl) propionic acid, was attempted by lipases in nearly anhydrous isooctane. The nature of the alcohol affects the reactivity and enant...
Efficient kinetic resolution of (R,S)-1-trimethylsilylethanol via lipase-mediated enantioselective acylation in ionic liquids.Chirality 18(10) , 814-21, (2006)
Efficient enantioselective acylation of (R,S)-1-trimethylsilylethanol {(R,S)-1-TMSE} with vinyl acetate catalyzed by immobilized lipase from Candida antarctica B (i.e., Novozym 435) was successfully c...
E. Vedejs, G.R. MartinezJ. Am. Chem. Soc. 101 , 6452, (1979)