SSR 125543A

Names

[ Name ]:
SSR 125543A

[Synonym ]:
2-Thiazolamine, 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-2-propyn-1-yl-, hydrochloride (1:1)
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-1,3-thiazol-2-amine hydrochloride (1:1)

Biological Activity

[Description]:

Crinecerfont (SSR-125543) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont can be used for Classic congenital adrenal hyperplasia (CAH) research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR

Research Areas >> Metabolic Disease

[Target]

IC50: CRF1 receptor

[References]

[1]. Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia (CAHtalyst).

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₉Cl₂FN₂OS

[ Molecular Weight ]:
519.501

[ Exact Mass ]:
518.136169

Related Compounds

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