3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid

Names

[ CAS No. ]:
320-77-4

[ Name ]:
3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid

[Synonym ]:
1-hydroxypropane-1,2,3-tricarboxylic acid
1-Hydroxy-propan-1,2,3-tricarbonsaeure
1-hydroxy-propane-1,2,3-tricarboxylic acid
3-Methylsaeure-pentanol-(2)-disaeure
I-CIT
D-isocitrate
isocitrate
1-Hydroxytricarballylic acid
1-Hydroxy-1,2,3-propanetricarboxylic acid
3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid

Biological Activity

[Description]:

Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia[1][2][3].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Tsuruoka M, et al. Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72.

[3]. Zupke C, et al. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36.