3,5-Dichloro-2-hydroxybenzoic acid
Names
[ CAS No. ]:
320-72-9
[ Name ]:
3,5-Dichloro-2-hydroxybenzoic acid
[Synonym ]:
3,5-Cl2salH
3,5-Dichlorosalicylic acid
Salicylic acid,3,5-dichloro
Benzoic acid,3,5-dichloro-2-hydroxy
USAF DO-68
Benzoic acid, 3,5-dichloro-2-hydroxy-
EINECS 206-281-8
2-Hydroxy-3,5-dichlorobenzoic acid
3,5-dichloro-2-hydroxy-benzoic acid
3,5-Dichloro-2-hydroxybenzoic acid
MFCD00002442
Chemical & Physical Properties
[ Density]:
1.7±0.1 g/cm3
[ Boiling Point ]:
319.3±42.0 °C at 760 mmHg
[ Melting Point ]:
221-224 °C
[ Molecular Formula ]:
C7H4Cl2O3
[ Molecular Weight ]:
207.011
[ Flash Point ]:
146.9±27.9 °C
[ Exact Mass ]:
205.953751
[ PSA ]:
57.53000
[ LogP ]:
4.40
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.641
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VO2450000
- CHEMICAL NAME :
- Salicylic acid, 3,5-dichloro-
- CAS REGISTRY NUMBER :
- 320-72-9
- BEILSTEIN REFERENCE NO. :
- 2210803
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C7-H4-Cl2-O3
- MOLECULAR WEIGHT :
- 207.01
- WISWESSER LINE NOTATION :
- QVR BQ CG EG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S37/39-S26
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
VO2450000
[ HS Code ]:
2918290000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918290000
[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
Articles
Phys. Chem. Chem. Phys. 14(25) , 8892-902, (2012)
The present work demonstrates a detailed characterization of the interaction of a bio-active drug molecule 3,5-dichlorosalicyclic acid (3,5DCSA) with a model transport protein Bovine Serum Albumin (BS...
Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity.Arch. Biochem. Biophys. 479(1) , 82-7, (2008)
The structure of aldehyde reductase (ALR1) in ternary complex with the coenzyme NADPH and 3,5-dichlorosalicylic acid (DCL), a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1), w...