N-CHLOROACETYLISONIPECOTIC ACID

Names

[ Name ]:
N-CHLOROACETYLISONIPECOTIC ACID

[Synonym ]:
N-Chloroacetylisonipecotic acid
1-(2-CHLOROACETYL)-4-PIPERIDINECARBOXYLIC ACID
1-chloroacetylpiperidine-4-carboxylic acid
MFCD02093986

Biological Activity

[Description]:

MurA-IN-4 has antibacterial activity and is a MurA inhibitor that inhibits bacterial cell wall synthesis[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Grabrijan K, et al. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. Eur J Med Chem. 2022 Dec 5;243:114752.

Chemical & Physical Properties

[ Density]:
1.349g/cm3

[ Boiling Point ]:
406.2ºC at 760 mmHg

[ Melting Point ]:
109-111ºC

[ Molecular Formula ]:
C₈H₁₂ClNO₃

[ Molecular Weight ]:
205.64

[ Flash Point ]:
199.4ºC

[ Exact Mass ]:
205.05100

[ PSA ]:
57.61000

[ LogP ]:
0.48630

[ Index of Refraction ]:
1.526

Safety Information

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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