Mycro1

Names

[ Name ]:
Mycro1

Biological Activity

[Description]:

Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Mycro1(10 or 20 μM, 7 days)可以抑制 C-Myc 依赖细胞系 U-2OS、MCF-7、Raji 和 NIH/3T3 的增殖，不会抑制 C-Myc 独立癌细胞株 PC-12 的增殖。Mycro1 在 10 μM 时可以显著抑制 c- myc 诱导的基因转录，在 20 μM 时可以选择性减少 c- myc 转化Rat1a细胞的非锚定生长[1]。

[References]

[1]. Anke Kiessling, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₅F₃N₄O₂S

[ Molecular Weight ]:
432.42

Related Compounds

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