BMS-684

Names

[ Name ]:
BMS-684

Biological Activity

[Description]:

BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

IC50: 15 nM (DGKα)[1]

[References]

[1]. Michael Wichroski, et al. DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Sci Transl Med. 2023 Oct 25;15(719):eadh1892.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₆N₄O₃

[ Molecular Weight ]:
454.52

Related Compounds

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