IGS-1.76

Names

[ Name ]:
IGS-1.76

[Synonym ]:
Benzenepropanamide, N-2-benzothiazolyl-β-phenyl-
N-(1,3-Benzothiazol-2-yl)-3,3-diphenylpropanamide

Biological Activity

[Description]:

IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1); demonstrates improved binding potency over the phenothiazine FD44, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model.

[References]

References 1. Roca C, et al. J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00088. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₂H₁₈N₂OS

[ Molecular Weight ]:
358.456

[ Exact Mass ]:
358.113983

[ LogP ]:
5.65

[ Index of Refraction ]:
1.700

[ Storage condition ]:
-20°C

Related Compounds

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