313480-47-6
313480-47-6 structure
- Name: IGS-1.76
- Chemical Name: N-(1,3-Benzothiazol-2-yl)-3,3-diphenylpropanamide
- CAS Number: 313480-47-6
- Molecular Formula: C22H18N2OS
- Molecular Weight: 358.456
- Create Date: 2020-01-11 16:08:36
- Modify Date: 2024-05-04 18:47:30
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IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1); demonstrates improved binding potency over the phenothiazine FD44, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model.
| Name | N-(1,3-Benzothiazol-2-yl)-3,3-diphenylpropanamide |
|---|---|
| Synonyms |
Benzenepropanamide, N-2-benzothiazolyl-β-phenyl-
N-(1,3-Benzothiazol-2-yl)-3,3-diphenylpropanamide |
| Description | IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1); demonstrates improved binding potency over the phenothiazine FD44, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. |
|---|---|
| References | References 1. Roca C, et al. J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00088. View Related Products by Target Other Targets |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H18N2OS |
| Molecular Weight | 358.456 |
| Exact Mass | 358.113983 |
| LogP | 5.65 |
| Index of Refraction | 1.700 |
| Storage condition | -20°C |