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TCS JNK 5a

Names

[ CAS No. ]:
312917-14-9

[ Name ]:
TCS JNK 5a

[Synonym ]:
F0016-0404
1-Naphthalenecarboxamide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
JNK Inhibitor IX
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthamide
TCS JNK 5a
SC-20267
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide

Biological Activity

[Description]:

TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> JNK
Research Areas >> Cancer

[Target]

JNK3:6.7 (pIC50)

JNK2:6.5 (pIC50)


[In Vitro]

TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them[1].

[References]

[1]. Angell RM, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.


[Related Small Molecules]

Pyrazolanthrone (SP600125) | JNK-IN-8 | Tomatidine | CC-930 | Astragaloside IV | D-JNKI-1 | AS601245 | JNK-IN-7 | BI 78D3 | DB07268 | SR-3306 | Bentamapimod | CC-401 | Ginsenoside Re | Isovitexin

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
486.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H16N2OS

[ Molecular Weight ]:
332.419

[ Flash Point ]:
248.2±28.7 °C

[ Exact Mass ]:
332.098328

[ PSA ]:
81.13000

[ LogP ]:
5.46

[ Appearance of Characters ]:
light yellow solid

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.699

[ Storage condition ]:
Store at RT

Safety Information

Related Compounds

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