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Zalypsis

Names

[ CAS No. ]:
308359-57-1

[ Name ]:
Zalypsis

Biological Activity

[Description]:

Zalypsis (PM00104) has anti-tumor activity. Zalypsis binds to DNA and shows cytotoxicity. Zalypsis inhibits cell cycle and transcription, and leads to double stranded DNA breaks[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Duan Z, et al. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol. 2009 May;63(6):1121-9.  

[2]. Petek BJ, et al. PM00104 (Zalypsis®): a marine derived alkylating agent. Molecules. 2014 Aug 15;19(8):12328-35.  

Chemical & Physical Properties

[ Molecular Formula ]:
C37H38F3N3O8

[ Molecular Weight ]:
709.71

Related Compounds