Hexamethylene bisacetamide

Names

[ Name ]:
Hexamethylene bisacetamide

[Synonym ]:
N,N‘-Hexamethylenebisacetamide
N,N'-hexamethylene bis(acetamide)
Hexamethylenediacetamide
N,N'-diacetyl-1,6-hexanediamine
hmba
N,N′-Diacetyl-1,6-diaminohexane
diacetyldiaminohexane
EINECS 211-363-1
hexamethylenebis(acetamide)
N,N-Hexamethylenediacetamide
N,N'-DIACETYL-1,6-DIAMINOHEXANE
MFCD00008684

Biological Activity

[Description]:

Hexamethylene bisacetamide is a tumor cell-differentiating agent[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Reuben RC, et al. A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc Natl Acad Sci U S A. 1976 Mar;73(3):862-6.

Chemical & Physical Properties

[ Density]:
0.974 g/cm3

[ Boiling Point ]:
456.7ºC at 760 mmHg

[ Melting Point ]:
128-129 °C(lit.)

[ Molecular Formula ]:
C₁₀H₂₀N₂O₂

[ Molecular Weight ]:
200.28

[ Flash Point ]:
193.2ºC

[ Exact Mass ]:
200.15200

[ PSA ]:
58.20000

[ LogP ]:
1.60080

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC2976200

CHEMICAL NAME :: Acetamide, N,N'-hexamethylenebis-

CAS REGISTRY NUMBER :: 3073-59-4

BEILSTEIN REFERENCE NO. :: 1775764

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H20-N2-O2

MOLECULAR WEIGHT :: 200.32

WISWESSER LINE NOTATION :: 1VM6MV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4270 mg/kg/10D-C

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - thrombocytopenia

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,5788,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
R33:Danger of cumulative effects.

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AC2976200

[ HS Code ]:
2924199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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