3,3'-Diethylthiatricarbocyanine iodide

Names

[ Name ]:
3,3'-Diethylthiatricarbocyanine iodide

[Synonym ]:
3,3'-diethyl-2,2'-thiadicarbocyanine iodide
3-Ethyl-2-[7-[3-ethyl-2(3H)-benzothiazolylidene]-1,3,5-heptatrienyl]benzothiazolium Iodide
DTTC IODIDE
3,3'-Diethylthiatricarbocyanine Iodide
THIATRICARBOCYANINE IODIDE,3,3'-DIETHYL
oliumiodide
DTTCI
NK-126
AURORA KA-295
MFCD00041994
3,3'-diethylthiatricarbocyanine
diethylthiatricarbocyanine iodide
3,3'-DIETHYL-2,2'-THIATRICARBOCYANINE IODIDE
1,7-bis-(3-ethyl-benzothiazol-2-yl)-heptamethinium,iodide
DTTC
EINECS 221-342-9

Biological Activity

[Description]:

3,3′-Diethylthiatricarbocyanine iodide is an infrared photographic sensitizing dye. 3,3′-Diethylthiatricarbocyanine iodide is a highly sensitive chiroptical reporter of DNA helicity and sequence[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Choi JK, et al. 3,3'-diethylthiatricarbocyanine iodide: a highly sensitive chiroptical reporter of DNA helicity and sequence. Int J Mol Sci. 2011;12(11):8052-62.

[2]. J. A. Potenza, et al. Crystal and molecular structure of 3,3'-diethylthiatricarbocyanine iodide, an infrared photographic sensitizing dye. Acta Cryst. (1978). B34, 193-199.

Chemical & Physical Properties

[ Melting Point ]:
211ºC (dec.)(lit.)

[ Molecular Formula ]:
C₂₅H₂₅IN₂S₂

[ Molecular Weight ]:
544.51400

[ Exact Mass ]:
544.05000

[ PSA ]:
65.29000

[ LogP ]:
3.13620

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL7045000

CHEMICAL NAME :: Benzothiazolium, 3-ethyl-2-(7-(3-ethyl-2-benzothiazolinylidene)-1,3,5- heptatrienyl)-, iodide

CAS REGISTRY NUMBER :: 3071-70-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H25-N2-S2.I

MOLECULAR WEIGHT :: 544.54

WISWESSER LINE NOTATION :: T56 BNYSJ B2 CU2U2U2U1- CT56 BK DSJ B2 &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,897,1967

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26;S36/S37

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
DL7045000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Articles

Structure-activity relationship of cyanine tau aggregation inhibitors.

J. Med. Chem. 52 , 3539-47, (2009)

A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine...

Three-dimensional fluorescence lifetime tomography.

Med. Phys. 32(4) , 992-1000, (2005)

Near-infrared fluorescence tomography using molecularly targeted lifetime-sensitive, fluorescent contrast agents have applications for early-stage cancer diagnostics. Yet, although the measurement of ...

Ionic dependence of membrane potential and glutamate receptor-linked responses in synaptoneurosomes as measured with a cyanine dye, DiS-C2-(5).

J. Neurochem. 48(2) , 552-9, (1987)

Membrane potentials of particles present in a subcellular brain preparation, called synaptoneurosomes, have been monitored by measurement of changes in the absorbance of a cyanine dye, DiS-C2-5. The m...