TCID

Names

[ Name ]:
TCID

[Synonym ]:
1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro-
4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione
Ubiquitin C-Terminal Hydrolase L3 Inhibitor
Ubiquitin Thiolesterase L3 Inhibitor
4,5,6,7-Tetrachloroindan-1,3-dione
4,5,6,7-Tetrachlorindan-1,3-dion
4,5,6,7-Tetrachlorphenyl-1,3-indandion
4,5,6,7-tetrachloroindane-1,3-dione
UCH-L3 Inhibitor
TCID
Ubiquitin C-Terminal Esterase L3 Inhibitor

Biological Activity

[Description]:

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM[1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

[Target]

IC50: 0.6 μM (UCH-L3) and 75 μM (UCH-L1)[1]

[In Vitro]

TCID (4,5,6,7-Tetrachloroindan-1,3-dione; compound 11) inhibits UCH-L1 with an IC50 of 75 μM[1]. TCID (10 μM; 1, 2 hours) diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].

[References]

[1]. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cellline. Chem Biol. 2003 Sep;10(9):837-46.

[2]. de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013;8(3):e58863.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
448.1±45.0 °C at 760 mmHg

[ Melting Point ]:
218-220ºC

[ Molecular Formula ]:
C₉H₂Cl₄O₂

[ Molecular Weight ]:
283.923

[ Flash Point ]:
188.8±29.3 °C

[ Exact Mass ]:
281.880890

[ PSA ]:
34.14000

[ LogP ]:
3.94

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.652

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2914700090

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%