4'-Ethynyl-2'-deoxyadenosine

Names

[ Name ]:
4'-Ethynyl-2'-deoxyadenosine

Biological Activity

[Description]:

4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[Target]

EC50: 98 nM (MT-4 cells)[1].

[References]

[1]. Ohrui H, et al. 4'-C-substituted-2'-deoxynucleosides: a family of antiretroviral agents which are potent against drug-resistant HIV variants. Curr Drug Targets Infect Disord. 2001 May;1(1):1-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₃N₅O₃

[ Molecular Weight ]:
275.26

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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