Perfluorodecalin

Names

[ CAS No. ]:
306-94-5

[ Name ]:
Perfluorodecalin

[Synonym ]:
OCTADECAFLUORODECALIN
perflunafene
perfluorodecahydronaphthalene
F-DC
Naphthalene, 1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-octadecafluorodecahydro-
perfluorodecahydronaphthalin
Perfluorodecalin
pfd
Octadecafluorodecaline
PP 5
EINECS 206-192-4
Perfluoro(decahydronaphthalene)
Octadecafluorodecahydronaphthalene
1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-octadecafluorodecalin
MFCD00010626
perfluorodecaline

Biological Activity

[Description]:

Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Orzalesi N, et al. Experimental short-term tolerance to perfluorodecalin in the rabbit eye: a histopathological study. Curr Eye Res. 1998;17(8):828-835.

[2]. Bourke RD, et al. Experimental long-term vitreous replacement with purified and nonpurified perfluorodecalin. Am J Ophthalmol. 1994;118(3):403-404.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
143.1±40.0 °C at 760 mmHg

[ Melting Point ]:
-10ºC

[ Molecular Formula ]:
C₁₀F₁₈

[ Molecular Weight ]:
462.078

[ Flash Point ]:
46.4±19.1 °C

[ Exact Mass ]:
461.971252

[ LogP ]:
6.03

[ Vapour density ]:
17.5 (vs air)

[ Vapour Pressure ]:
6.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.296

[ Water Solubility ]:
Insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ3175000

CHEMICAL NAME :: Naphthalene, decahydrooctadecafluoro-

CAS REGISTRY NUMBER :: 306-94-5

BEILSTEIN REFERENCE NO. :: 2067113

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-F18

MOLECULAR WEIGHT :: 462.10

WISWESSER LINE NOTATION :: L66TJ AF BF BF CF CF DF DF EF EF FF GF GF HF HF IF IF JF JF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >100 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MayGF# Personal Communication from Dr. G.F. May, BNFL Fluorochemicals Ltd., Bldg. 619, Springfields, Salwick, Preston, Lancashire PR4 OXJ. UK, Aug. 25, 1995. Volume(issue)/page/year: 25AUG1995

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8647 ppm/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB81-156911

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PGPKA8 Problemy Gematologii i Perelivaniia Krovi. Problems of Hematology and Blood Transfusion. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1956- Volume(issue)/page/year: 27(10),8,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 90,1513,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4449 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R10

[ Safety Phrases ]:
S24/25-S41

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
QJ3175000

[ Packaging Group ]:
III

[ Hazard Class ]:
3.2

[ HS Code ]:
2903999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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