Polidocanol

Names

[ Name ]:
Polidocanol

[Synonym ]:
3,6,9,12,15,18,21,24,27-Nonaoxanonatriacontan-1-ol
Polidocanol
MFCD00043375
Nonaethyleneglycol monododecyl ether solution
EINECS 221-284-4
2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Nonaethyleneglycol monododecylether
Dodecyl nonaethylene glycol ether
dodecylalcohol nonaethoxylate
nonaoxyethylene monododecyl ether
C12E9,Dodecyl nonaethylene glycol ether,Dodecylnonaglycol
Dodecylnonaglycol
C12E9

Biological Activity

[Description]:

Nonaethylene glycol monododecyl ether (Nonaoxyethylene monododecyl ether) is a nonionic surfactant and polyethylene glycol (PEG) detergent that can be used to form initial coalesced O/W emulsion droplets, as well as for protein separation and purification[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Examination of a series of non-ionic PEG detergents with several long-chain E-PDSs from different organisms reveals that in vitro incubations with Nonaethylene glycol monododecyl ether typically gave chain lengths that corresponded to those of the isoprenoid moieties in respiratory quinones synthesized in vivo[2].

[References]

[1]. Li C, et al. Oil-in-Water Emulsion Templated and Crystallization-Driven Self-Assembly Formation of Poly(l-lactide)-Polyoxyethylene-Poly(l-lactide) Fibers. Langmuir. 2017 Nov 14;33(45):13060-13067.

[2]. Pan JJ, et al. Dependence of the product chain-length on detergents for long-chain E-polyprenyl diphosphate synthases. Biochemistry. 2013 Jul 23;52(29):5002-8.

[3]. Zhang W, et al. Comparison of the different types of surfactants for the effect on activity and structure of soybean peroxidase. Langmuir. 2009 Feb 17;25(4):2363-8.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
615.9±50.0 °C at 760 mmHg

[ Melting Point ]:
33-36ºC

[ Molecular Formula ]:
C₃₀H₆₂O₁₀

[ Molecular Weight ]:
582.807

[ Flash Point ]:
326.3±30.1 °C

[ Exact Mass ]:
582.434326

[ PSA ]:
103.30000

[ LogP ]:
2.18

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.459

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Safety Phrases ]:
23-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Protein release from electrospun nonwovens: improving the release characteristics through rational combination of polyester blend matrices with polidocanol.

Int. J. Pharm. 477(1-2) , 273-81, (2014)

Nonwoven scaffolds consisting of poly-ε-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) and polidocanol (PD), and loaded with lysozyme crystals were prepared by electrospinning. The compositi...

Ex Vivo and In Vivo Lentivirus-Mediated Transduction of Airway Epithelial Progenitor Cells.

Curr. Gene Ther. 15 , 581-90, (2015)

A key challenge in pulmonary gene therapy for cystic fibrosis is to provide long-term correction of the genetic defect. This may be achievable by targeting airway epithelial stem/progenitor cells with...

A dispersive liquid-liquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultra-high-performace liquid chromatography with DAD detection.

Biomed. Chromatogr. 29(3) , 353-6, (2015)

A dispersive liquid-liquid micellar microextraction (DLLMME) method coupled with ultra-high-performance liquid chromatography (UHPLC) using Diode Array Detector (DAD) detector was developed for the an...