Brilliant yellow

Names

[ Name ]:
Brilliant yellow

[Synonym ]:
Brilliantgelb
EINECS 221-267-1
Sodium 4,4'-bis(p-hydroxyphenylazo)-2,2'-vinylenedibenzenesulphonate
C.I.DIRECTYELLOW4
Brilliant yellow
Fenamin Yellow 3G
Disodium 2,2'-(E)-ethene-1,2-diylbis{5-[(E)-(4-hydroxyphenyl)diazenyl]benzenesulfonate}
DIRECT YELLOW
Benzenesulfonic acid, 2,2'-[(E)-1,2-ethenediyl]bis[5-[(E)-2-(4-hydroxyphenyl)diazenyl]-, sodium salt (1:2)
MFCD00007489
Direct Yellow RCH
Brillantyellow
Brightyellow
Direct Yellow 4
Disodium 2,2'-[(E)-1,2-ethenediyl]bis{5-[(E)-(4-hydroxyphenyl)diazenyl]benzenesulfonate}

Biological Activity

[Description]:

Brilliant Yellow, a diazo-containing sulfonic aci, is also a potent VGLUT-specific inhibitor. Brilliant Yellow is membrane-impermeable. However, there are some Brilliant Yellow analogs with low cytotoxicity and cell penetration. Brilliant Yellow analogs work on glutamatergic transmission in hippocampal neurons[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

VGLUT[1]

[References]

[1]. Kehrl J, et al. Vesicular Glutamate Transporter Inhibitors: Structurally Modified Brilliant Yellow Analogs. Neurochem Res. 2017 Jun;42(6):1823-1832.

Chemical & Physical Properties

[ Density]:
1.5 g/cm3

[ Molecular Formula ]:
C₂₆H₁₈N₄Na₂O₈S₂

[ Molecular Weight ]:
624.55

[ Exact Mass ]:
624.036133

[ PSA ]:
221.06000

[ LogP ]:
8.06880

[ Index of Refraction ]:
1.691

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
3204140000

Customs

[ HS Code ]: 3204140000

Articles

Diazacoronand linked beta-cyclodextrin dimer complexes of Brilliant Yellow tetraanion and their sodium(I) analogues.

Org. Biomol. Chem. 1(5) , 887-94, (2003)

Complexation of the Brilliant Yellow tetraanion, 3(4-), by two new diazacoronand linked beta-cyclodextrin (beta CD) dimers 4,13-bis(2-(6A-deoxy-beta-cyclodextrin-6A-yl)aminooctylamidomethyl- and 4,13-...

Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults.

Environ. Sci. Pollut. Res. Int. 19(6) , 2438-47, (2012)

Valproic acid and its sodium salt (sodium valproate) are antiepileptic drugs that are sometimes used to treat chronic neuropathic pain and fibromyalgia, although they are not licensed for this use.To ...

Multilayered assemblies composed of brilliant yellow and poly(allylamine) for an optical pH sensor.

Anal. Sci. 22(8) , 1117-9, (2006)

Multilayered thin films containing poly(allylamine) (PAA) and brilliant yellow (BY) were prepared on a quartz slide by a layer-by-layer (LBL) deposition technique. The UV-visible spectra of the PAA/BY...