Exo2

Names

[ Name ]:
Exo2

Biological Activity

[Description]:

Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells[1][2].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Others

[References]

[1]. Spooner RA, et al. The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochem J. 2008 Sep 15;414(3):471-84.

[2]. Morgan A, et al. Exo1 and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells. Nature. 1992 Feb 27;355(6363):833-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₈N₄O₂S

[ Molecular Weight ]:
354.42600

[ Exact Mass ]:
354.11500

[ PSA ]:
107.87000

[ LogP ]:
3.80330

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in HC11 mouse mammary epithelial cells.

Cell Biol. Int. 40 , 143-55, (2016)

The cytosolic lipid droplets (cLDs) store excess intracellular lipids, and perilipin-2 is believed to protect cLDs from degradation. Here, we investigated the role of the small G-protein Arf1 and the ...

Related Compounds

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