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LU AA33810

Names

[ CAS No. ]:
304008-29-5

[ Name ]:
LU AA33810

Biological Activity

[Description]:

Lu AA33810 is a potent and selective antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the human receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[Target]

hY5 receptor:1.5 nM (Ki)


[References]

[1]. Walker MW, et al. The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 2009 Mar;328(3):900-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H25N3O2S3

[ Molecular Weight ]:
423.61600

[ Exact Mass ]:
423.11100

[ PSA ]:
136.24000

[ LogP ]:
4.87180

Related Compounds