5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine

Names

[ Name ]:
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine

Biological Activity

[Description]:

5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₂N₂O₇S

[ Molecular Weight ]:
576.66