1,4-Bis[(2H)sulfanyl]-2,3-(2H6)butane(2H2)diol

Names

[ Name ]:
1,4-Bis[(2H)sulfanyl]-2,3-(2H6)butane(2H2)diol

[Synonym ]:
DL-Dithiothreitol-d10
Cleland's reagent-d10
1,4-Bis[(H)sulfanyl]-2,3-(H)butane(H)diol
2,3-Butane-1,1,2,3,4,4-d-diol-d, 1,4-di(mercapto-d)-
Cleland inverted exclamation mark s reagent-d10
MFCD00190434

Biological Activity

[Description]:

DL-dithiothreitol-d10 is the deuterium labeled DL-dithiothreitol[1]. DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Dithiothreitol, From Wikipedia

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
364.5±42.0 °C at 760 mmHg

[ Melting Point ]:
42-44ºC(lit.)

[ Molecular Formula ]:
C₄D₁₀O₂S₂

[ Molecular Weight ]:
164.313

[ Flash Point ]:
174.2±27.9 °C

[ Exact Mass ]:
164.074982

[ PSA ]:
118.06000

[ LogP ]:
0.07

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.579

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport