Boc-N-PEG2-Ms

Names

[ CAS No. ]:
302331-20-0

[ Name ]:
Boc-N-PEG2-Ms

[Synonym ]:
2-[2-(tert-Butoxycarbonylamino)ethoxy]ethyl methanesulfonate
1-(2-(tert-butyloxycarbonylamino)ethoxy)-2-sulfonylethane
2-(2-(tert-butoxycarbonylamino)ethoxy)ethyl methanesulfonate
2-[2-(tert-butoxycarbonylamino)ethoxy]ethyl methanesulfonate
2-(2-((tert-butoxycarbonyl)amino)ethoxy)ethyl methanesulfonate
2-{2-[(tert-butoxycarbonyl)amino]ethoxy}ethyl methanesulfonate

Biological Activity

[Description]:

Boc-N-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C10H21NO6S

[ Molecular Weight ]:
283.34200

[ Exact Mass ]:
283.10900

[ PSA ]:
99.31000

[ LogP ]:
1.97560

Related Compounds