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ALLOTETRAHYDROCORTISOL

Names

[ CAS No. ]:
302-91-0

[ Name ]:
ALLOTETRAHYDROCORTISOL

[Synonym ]:
KENDALL'S COMPOUND 'C'
Allotetrahydrocortisol
ALLO THF
5a-Tetrahydrocortisol
REICHSTEIN'S SUBSTANCE 'C'
KENDALL'S COMPUND ''C''

Biological Activity

[Description]:

Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes[1][2].

[Related Catalog]:

Research Areas >> Others

[Target]

Human Endogenous Metabolite


[In Vitro]

Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a natural C21 steroid of animal origin, and has the axial configuration of its 3-hydroxyl group[1].

[References]

[1]. BUSH IE, et al. The excretion of allo tetrahydrocortisol in human urine. Biochem J. 1957 Dec;67(4):689-700.

[2]. Kosicka K, et al. Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MS. J Pharm Biomed Anal. 2017 Jun 5;140:174-181.

Chemical & Physical Properties

[ Density]:
1.253g/cm3

[ Boiling Point ]:
545.1ºC at 760mmHg

[ Melting Point ]:
244.5ºC

[ Molecular Formula ]:
C21H34O5

[ Molecular Weight ]:
366.49200

[ Flash Point ]:
297.6ºC

[ Exact Mass ]:
366.24100

[ PSA ]:
97.99000

[ LogP ]:
1.65330

[ Index of Refraction ]:
1.579

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds