Cleistanthin B

Names

[ Name ]:
Cleistanthin B

Biological Activity

[Description]:

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

Research Areas >> Metabolic Disease

[Target]

IC50: 6.51 µM (SARS-CoV-2)[1]

[In Vitro]

Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM[1]. Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM[1].

[In Vivo]

Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor[2].

[References]

[1]. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471.

[2]. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388.

[3]. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7.

[4]. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₆O₁₂

[ Molecular Weight ]:
542.48800

[ Exact Mass ]:
542.14200

[ PSA ]:
162.60000

[ LogP ]:
1.10180

[ Storage condition ]:
2-8°C

Related Compounds

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