30021-77-3
30021-77-3 structure
- Name: Cleistanthin B
- Chemical Name: cleistanthin B
- CAS Number: 30021-77-3
- Molecular Formula: C27H26O12
- Molecular Weight: 542.48800
- Catalog: Signaling Pathways Anti-infection SARS-CoV
- Create Date: 2017-09-20 02:25:03
- Modify Date: 2024-01-16 10:49:25
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Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].
| Name | cleistanthin B |
|---|
| Description | Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4]. |
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| Related Catalog | |
| Target |
IC50: 6.51 µM (SARS-CoV-2)[1] |
| In Vitro | Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM[1]. Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM[1]. |
| In Vivo | Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor[2]. |
| References |
| Molecular Formula | C27H26O12 |
|---|---|
| Molecular Weight | 542.48800 |
| Exact Mass | 542.14200 |
| PSA | 162.60000 |
| LogP | 1.10180 |
| Storage condition | 2-8°C |