(Pro3)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt

Names

[ Name ]:
(Pro3)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt

Biological Activity

[Description]:

(Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) is an efficacious, stable and specific human GIP receptor (hGIPR) full agonist. (Pro3) GIP, human has high binding affinity for human GIPR with Ki/ Kd values of 0.90 nM. (Pro3) GIP, human can be used for the research of obesity-related diabetes[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor

[Target]

EC50: 0.026 nM (hGIPR)[2] Ki/Kd: 0.90 nM (hGIPR); 1.1 nM (Rat GIPR); 0.72 nM (Mouse GIPR)[2]

[In Vitro]

(Pro3) GIP, human induces cAMP accumulation with an EC50 value of 0.026 nM[2]. (Pro3) GIP, human has high binding affinity for human GIPR, Rat GIPR and Mouse GIPR with Ki/ Kd values of 0.90 nM, 1.1 nM and 0.72 nM, respectively[2].

[In Vivo]

(Pro3) GIP, human has comparatively weak partial agonist effect in rodent models[2].

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂₆H₃₃₈N₆₀O₆₄S

Related Compounds

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