VEGFR-2-IN-37

Names

[ Name ]:
VEGFR-2-IN-37

[Synonym ]:
3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone

Biological Activity

[Description]:

VEGFR-2-IN-37 (compound 12) is an inhibitor of VEGFR-2. The inhibition rate at 200 μM was approximately 56.9 μM. VEGFR-2-IN-37 is a potential inhibitor of human umbilical vein endothelial cell (HUVEC) proliferation[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR-2[1]

[References]

[1]. Perspicace E, et al. Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2). Eur J Med Chem. 2013 May;63:765-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₆N₂O₂S

[ Molecular Weight ]:
324.40

Related Compounds

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