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Desmethylbellidifolin

Names

[ CAS No. ]:
2980-32-7

[ Name ]:
Desmethylbellidifolin

[Synonym ]:
Demethylbellidifolin
Xanthen-9-one,1,3,5,8-tetrahydroxy
Desmethylbellidifolin
Bellidin
norbellidifolin
1,3,5,8-tetrahydroxyxanthone
Desmethybellidifolin
norbellidifodin
1,3,5,8-Tetrahydroxy-9H-xanthen-9-one
9H-Xanthen-9-one, 1,3,5,8-tetrahydroxy-
1,3,5,8-tetrahydroxy-xanthen-9-one
1,3,5,8-tetrahydroxyxanthen-9-one

Biological Activity

[Description]:

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[In Vitro]

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) attenuates lipopolysaccharide-induced nitric oxide release and proinflammatory cytokine expression in RAW264.7 cells[1].

[In Vivo]

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin; orally; 5, 10, 20 mg/kg; 12 days) can inhibit trinitrobenzenesulfonic acid (TNBS)-induced ulcerative colitis (UC), reducing inflammatory response and alleviate colon muscle spasm[1].

[References]

[1]. Ni Y, et al. Desmethylbellidifolin From Gentianella acuta Ameliorate TNBS-Induced Ulcerative Colitis Through Antispasmodic Effect and Anti-Inflammation. Front Pharmacol. 2019 Sep 20;10:1104. 

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
605.6±55.0 °C at 760 mmHg

[ Melting Point ]:
317ºC

[ Molecular Formula ]:
C13H8O6

[ Molecular Weight ]:
260.199

[ Flash Point ]:
242.0±25.0 °C

[ Exact Mass ]:
260.032074

[ PSA ]:
111.13000

[ LogP ]:
0.33

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.801

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZD6122300
CHEMICAL NAME :
Xanthen-9-one, 1,3,5,8-tetrahydroxy-
CAS REGISTRY NUMBER :
2980-32-7
BEILSTEIN REFERENCE NO. :
0286545
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H8-O6
MOLECULAR WEIGHT :
260.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
20 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 150,141,1985

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream