Altretamine (hydrochloride)

Names

[ Name ]:
Altretamine (hydrochloride)

[Synonym ]:
Altretamine hydrochloride
1,3,5-Triazine-2,4,6-triamine,N,N,N',N',N'',N''-hexamethyl-,monohydrochloride
2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine hydrochloride
Hexamethylmelamine HCl
Altretamine (hydrochloride)

Biological Activity

[Description]:

Altretamine hydrochloride is an alkylating antineoplastic agent.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker

Research Areas >> Cancer

[In Vitro]

Altretamine hydrochloride is an antineoplastic agent[1].

[In Vivo]

Altretamine (100, 133 mg/kg, ip.) in combination with Irofulven, increases the antitumor effect in mice bearing MV522 cells[1].

[Animal admin]

Mice[1] Balb/c nu/nu 4 week old female mice weighing 18-22 g, receive s.c. injections of 8-10 million MV522 cells. Altretamine is administered i.p. three times a week for 3 weeks, starting on day 10 after tumor implantation. Tumor size is measured in two perpendicular diameters and tumor weight (TW) estimated according to the formula: w = [(width)2 × length/2]. Altretamine is prepared as stock solutions of 1-10 mg/mL in 40% DMSO/normal saline and diluted with 10% DMSO/normal saline as required[1].

[References]

[1]. Kelner MJ, et al. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
339.4ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₉ClN₆

[ Molecular Weight ]:
246.74000

[ Flash Point ]:
159.1ºC

[ Exact Mass ]:
246.13600

[ PSA ]:
48.39000

[ LogP ]:
0.87160

[ Vapour Pressure ]:
9.2E-05mmHg at 25°C

[ Storage condition ]:
2-8℃

Altretamine (hydrochloride)

Names

Biological Activity

Chemical & Physical Properties

Related Compounds