Azido-PEG6-C1-Boc

Names

[ CAS No. ]:
297162-49-3

[ Name ]:
Azido-PEG6-C1-Boc

[Synonym ]:
AZIDO-PEG6-CH2CO2TBU

Biological Activity

[Description]:

Azido-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₅N₃O₈

[ Molecular Weight ]:
421.486

[ Exact Mass ]:
421.242401

[ LogP ]:
0.04

Azido-PEG6-C1-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds