297162-49-3

297162-49-3 structure

Name: Azido-PEG6-C1-Boc
Chemical Name: Azido-PEG6-CH2CO2t-butyl ester
CAS Number: 297162-49-3
Molecular Formula: C₁₈H₃₅N₃O₈
Molecular Weight: 421.486
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-12 23:14:38
Modify Date: 2024-01-14 23:13:22
Azido-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Azido-PEG6-CH2CO2t-butyl ester
Synonyms	AZIDO-PEG6-CH2CO2TBU

Description	Azido-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562