IRAK4-IN-28

Names

[ CAS No. ]:
2952532-92-0

[ Name ]:
IRAK4-IN-28

Biological Activity

[Description]:

IRAK4-IN-28 (compound 42) is an orally active IRAK4 inhibitor (IC50=8.9 nM). IRAK4-IN-28 has binding affinity for IRAK4 with a Kd of 0.58 nM. IRAK4-IN-28 can be used in the research of inflammation and autoimmune diseases[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> IRAK
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IC50:8.9 nM (IRAK4)[1], IC50:>30 nM (hERG)[1], Kd:0.58 nM (IRAK4)[1], Kd:140 nM (IRAK1)[1]


[References]

[1]. Yongjin Hao, et al. Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS-induced SIRS model. Bioorg Chem. 2023 , 137:106584.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H31N9O3

[ Molecular Weight ]:
529.59

Related Compounds

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