SIRT5 inhibitor 7

Names

[ CAS No. ]:
2951090-00-7

[ Name ]:
SIRT5 inhibitor 7

Biological Activity

[Description]:

SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Research Areas >> Inflammation/Immunology

[Target]

IC50: 310 nM (SIRT5)[1]


[References]

[1]. Mou L, et al. Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66(16):11517-11535..  

Chemical & Physical Properties

[ Molecular Formula ]:
C28H32ClN7O3S

[ Molecular Weight ]:
582.12

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.