IDO1/TDO-IN-6

Names

[ CAS No. ]:
2948772-71-0

[ Name ]:
IDO1/TDO-IN-6

Biological Activity

[Description]:

IDO1/TDO-IN-6 (compound 11) is a dual inhibitor of IDO1/TDO with IC50s of 2.25 and 2.89 μM, respectively. IDO1/TDO-IN-6 has inhibitory effects on IDO1 and TDO, with Ki values of 1.9 and 3.1 μM, respectively. IDO1/TDO-IN-6 can be used in cancer and immunology research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Research Areas >> Inflammation/Immunology

[References]

[1]. Mei-Fen Bao, et al. Discovery and biological evaluation of a new type of dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase from ethnomedicinal plant Dactylicapnos scandens. Phytochemistry. 2023, 214:113794.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H17NO5

[ Molecular Weight ]:
351.35

Related Compounds

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