TS-IN-2

Names

[ CAS No. ]:
2945983-00-4

[ Name ]:
TS-IN-2

Biological Activity

[Description]:

TS-IN-2 (compound 17) is a thymidylate synthase (TS) inhibitor with an IC50 of 0.81 μM. TS-IN-2 induces cancer cell apoptosis and cell cycle arrest in S phase, and also inhibit DNA synthesis, resulting in DNA damage[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Thymidylate Synthase
Research Areas >> Cancer

[References]

[1]. Syed Nazreen, et al. New Natural Eugenol Derivatives as Antiproliferative Agents: Synthesis, Biological Evaluation, and Computational Studies. ACS Omega. 2023 May 15;8(21):18811-18822.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H23N3O4S

[ Molecular Weight ]:
377.46

Related Compounds

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