Anticancer agent 128

Names

[ CAS No. ]:
2941243-62-3

[ Name ]:
Anticancer agent 128

Biological Activity

[Description]:

Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> IAP

[Target]

IC50: 27.2 nM (XIAP-BIR3), 16.6 nM (cIAP1-BIR3), and 8.4 nM (cIAP2-BIR3)[1]


[References]

[1]. Parima Udompholkul, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H38N4O4

[ Molecular Weight ]:
470.60

Related Compounds

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