h-NTPDase-IN-5

Names

[ Name ]:
h-NTPDase-IN-5

Biological Activity

[Description]:

h-NTPDase-IN-5 (compound 3b) is a pan-inhibitor of NTPDase with IC50s of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPDase2), 26.14 μM (h-NTPDase3), 0.32 μM (h- NTPDase8).

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Others

[Target]

IC50: 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPDase2), 26.14 μM (h-NTPDase3), 0.32 μM (h- NTPDase8)

[References]

[1]. Zaman G, Ullah S, Uzair M, et al. Synthesis of Thieno [3, 2‐d] pyrimidine Derivatives through Sequential SNAr and Suzuki Reactions as Selective h‐NTPDases Inhibitors[J]. ChemMedChem, 2023: e202300165.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁N₃O₂S

[ Molecular Weight ]:
403.50

Related Compounds

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