BI-2865

Names

[ Name ]:
BI-2865

Biological Activity

[Description]:

BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[References]

[1]. Kim D, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature. 2023 May 31.

Chemical & Physical Properties

[ Density]:
1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

[ Boiling Point ]:
708.7±70.0 °C(Predicted)

[ Molecular Formula ]:
C₂₃H₂₇N₇O₂S

[ Molecular Weight ]:
465.57

Related Compounds

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