Antifungal agent 68

Names

[ CAS No. ]:
2925307-53-3

[ Name ]:
Antifungal agent 68

Biological Activity

[Description]:

Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Campos Péret VA, et al. New miconazole-based azoles derived from eugenol show activity against Candida spp. and Cryptococcus gattii by inhibiting the fungal ergosterol biosynthesis. Eur J Med Chem. 2023 Aug 5;256:115436..  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H27ClN2O3

[ Molecular Weight ]:
414.93

Related Compounds

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