SJ1461

Names

[ Name ]:
SJ1461

Biological Activity

[Description]:

SJ1461 is a potent and orally active BET inhibitor. SJ1461 inhibits BRD2 (BD1), and BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with IC50 values of 1.6 nM, 0.1 nM, 6.5 nM, and 0.2 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD2 (BD1):1.6 nM (IC50)

BRD2 (BD2):0.1 nM (IC50)

BRD4 (BD1):6.5 nM (IC50)

BRD4 (BD2):0.2 nM (IC50)

[References]

[1]. Mladen Koravovic, et al. From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. Eur J Med Chem. 2023 May 5;251:115246.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈ClN₇OS₂

[ Molecular Weight ]:
484.00

Related Compounds

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