Tetradcylthioacetic acid

Names

[ Name ]:
Tetradcylthioacetic acid

[Synonym ]:
TETRADECYLTHIOACETIC ACID
(Tetradecylsulfanyl)acetic acid
MFCD00128230
Acetic acid, 2-(tetradecylthio)-
Tetradcylthioacetic acid
1-(carboxymethylthio)tetradecane

Biological Activity

[Description]:

2-Tetradecylthio acetic acid is a pan-peroxisome proliferator activated receptor (pan-PPAR) activator. 2-Tetradecylthio acetic acid induces hypolipidemia. 2-Tetradecylthio acetic acid reduces plasma lipids and enhances hepatic fatty acid oxidation in rodents. 2-Tetradecylthio acetic acid increases the expression of genes involved in fatty acid uptake, activation, accumulation, and oxidation[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

Research Areas >> Metabolic Disease

[References]

[1]. Vaagenes H, et al. Methylated eicosapentaenoic acid and tetradecylthioacetic acid: effects on fatty acid metabolism. Biochem Pharmacol. 1999 Oct 1;58(7):1133-43.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
402.6±28.0 °C at 760 mmHg

[ Melting Point ]:
65-73°C

[ Molecular Formula ]:
C₁₆H₃₂O₂S

[ Molecular Weight ]:
288.489

[ Flash Point ]:
197.3±24.0 °C

[ Exact Mass ]:
288.212311

[ PSA ]:
62.60000

[ LogP ]:
7.08

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.481

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
DMSO: ≥22 mg/mL, soluble

Safety Information

[ Hazard Codes ]:
Xi

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%